I suspect that there will be one generation of manned fighters past the F22/F35. Maybe two, though the second generation would definitely be a Human/AI combo working together (Yes, I've read Yukikaze, that's where I got the idea from). It's possible that the 6th generation would have an AI copilot, kinda depends on the software engineers at this point.
Past that, it's AI-controlled UCAVs basically told "anything flying in the following geographical area that doesn't pass IFF is to be shot down."
I think that there will be manned aircraft roles for decades to come, even fighters (especially air policing). But I also think for the US, and likely the PRC soon after, the effectiveness of a simple two AAM UAV at getting to with lethal range of anything else and shooting it down (and if necessary just taking the hit rather than b evading) is going to ignite an attritional war of UCAV vs manned, followed shortly their after by UCAV vs UCAV, with the kind of loss rates normally associated with WWII. I’m not sure a “star destroyer” type manned platform has any place in that environment. And if you want to just geo fence a UAV into an airspace that is a free fire zone devoid of friendly aircraft, then that seems completely achievable now.