I think it's just dependent on the situation, but I'd assume the best use case would be with long-range missiles instead of AMRAAMs or anything of the sort. Even if the Raider flies at high altitudes, the simple fact that it's slow as fuck would require A2A truck load-outs to be spec'd for range.While I would not be surprised if the B-21 had some kind of air to air capability for self defense, I cannot imagine that it would ever be used with an A2A focused payload. Firing an AAM is going to mark the aircraft’s position with a road flare for every launch event, heavily negating its stealth and putting a pricy, limited inventory asset at increased risk. Air to ground missiles would have a similar effect, but presumably the entire payload would be launched all once for an air to ground engagement. Glide munitions would not have a large IR event when released and are probably preferable.
More sensibly, there will probably be CUDA/AMRAAM-type missiles carried in the bay for self-defense on ground attack/ISR missions.