You probably wouldn't send a B-1 or B-52 to nail a single guy. If you wanted to mess up a truck column, or theatrically turn a building or an industrial area or a missile launch site or a mass of infantry or a gunboat or a cargo ship or a train or low flying helicopters or cargo planes into confetti, this would be a dandy way to do it. Orbit at 20,000 feet and drop five thousand rounds of 40MM on a target, the *right* *kind* of target, and you'll leave an impression. With a 40MM cannon, the possibility certainly exists to use guided rounds. Imagine having a 40MM cannon capable of nailing one guy from five miles up... thousands of times. The mission limitation might be fatigue in the on-board WSO, so the plane might have to have remote gunners.
Still, consider: a B-1 with a high-precision gun is available, and you've just found out that the leader of ISIS is going to be standing on such-and-such a balcony hundreds of miles into enemy territory in a few hours. Soon enough that a B-1 could get there, but not an Apache, not a SEAL sniper team. It might be worth it to send that B-1. The guy is standing there chatting with his buds when BLAMMO his chest is turned into a cavity. Everyone starts looking around but can't see diddly because the gun is *miles* up and *miles* away. The B-1 gunner (now that he has definite confirmation that the target is indeed toast) gets to decide whether to call it a day and leave the rest of the people wondering, or start plinking. Individuals would be too busy simulating Brownian motion to be individually targeted (unless the rounds are laser guided), but their vehicles and structures certainly could be. If you want to be especially entertaining, use rounds that detonate a meter or two prior to impact, thus making a real mess of soft targets.