Well, so far all manned airships have been limited to about 10,000 feet cruise altitude (some Zeppelins flew higher during WW I). I guess you could pressurize a gondola and fly higher, but then statistically you find higher windspeeds, which are very bad for airships. In a head wind, you might end up flying at 20 knots ground speed. The real advantage of blimps is station keeping in very light winds, where you have very long endurance because it takes very little power to stay aloft. Increase the required airspeed, and fixed-wing starts looking better.
The aerodynamics of airships tend to favor very large aircraft, because the friction coefficient goes down.
For large airships the problem of airport compatibility arises. Ground handling is also an issue. P-791 has the advantage of being able to use the fans at the bottom of the envelope as suction cups to pin itself to the ground or to help steer while taxiing. It is also of hybrid design, so the buoyancy is less than the weight. In order to fly, it needs some forward velocity, just like for fixed wings. This means that while on the ground, it's less likely to float around.