Maybe the solution is the MSDM?
USAF aircraft are getting a new self-defense weapon able to shoot down surface-to-air missiles, allowing them to operate in contested airspace.
www.forbes.com
It isn't an ideal scenario, you'd much rather defeat the targeting cycle at the find fix stage, but this seems a viable option for a large platform like this. Could also see a custom built tanker having a set of self defence drones attached to it that could provide close in defence of the aircraft in those types of scenarios.