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E85 will just evaporate in a small fraction in the intake of naturally aspirated engines and the large amount of evaporation heat hinders the homogenisation in the cylinder. Starting a MPI engine with E85 can be tricky and the engines will have problems with load changes. I drove quite a lot with "E60" (E85 plus some gazoline) without modifications in my old Astra, it worked well once the engine was warm.