To get his early questions in rocket development answered he and his Burbank, California based Hughes Aircraft Co. engineers could have gone to the Pasadena Jet Propulsion Lab to address rocketry, hardware design, and laboratory testing. From there Hughes could have funded Caltech university's research and explored some of the propellants and systems that needed to be developed. Conducting suborbital launches in Southern California.
With the early success of JPL's JATO (Jet-Assisted Take-Off) technology, Hughes could have applied the JATO systems to some early aircraft projects, pioneering rocket aircraft designs, and winning research projects away from Bell (e.g. the Hughes X-1
). Opening up another area for Hughes to develop spaceflight technologies.
Acting as the prime contractor, Hughes could have subcontracted much of the work out on the orbital launch vehicle. Forming a consortium between universities and industry, to offset the costs and utilize their brain trusts, Hughes could have evolved a group to launch an orbital vehicle.
As Michel said, his ability to access hardware is critical. If his funds or access were limited, his technology development timing off, his personal bout with schizophrenia disruptive, or a host of other factors, the US government and the Russians would beat him to orbit. Stealing his fire and leading to the already known course of history.