I found nice Reference Mission that use Nova Class booster
Study of Conjunction Class Manned Mars Trips, Douglas Aircraft Company,
SM-48661, Summary; SM-48662, Technical Details, Parts I & II, June 1965.
Their plan was to launch in 1980s six manned mars mission.
Mars Orbit Module and Mars Excursion Module launch together on a Nova Booster (with 80 foot diameter)
follow by Earth Departure Step on second Nova booster
Both rendezvous in orbit and Dock.
EDS launch the MoM/MeM to Mars were they aerodynamic-braking manoeuvre into Mars orbit.
Do Mars orbit around the Sun, somme mission will be either conjunction (1000 day) or Opposition with 600 day mission days.
To this the mass of EDS and MoM/MeM will change at each mission, since they stay chemical, they use Hydrogen / fluorine !!!