T-tails on any high speed airplane can be very dangerous, if not done correctly. This usually means preventing stalls or other high alpha maneuvres, with a reliable and/or fail operational stick pusher or equivalent. The prototype CL600 was lost in stall testing, which the manufacturer thought was not needed because of the stick pusher design. Many other t-tail swept wing airplanes get certified without ever stalling. You just have to prove that a stall is virtually impossible.
I think the question of where the engines go is fairly complicated, and is a trade off, like anything else in airplane design. The 727 was optimized for relatively short field performance, so the aerodynamic penalty of engines on the wing was not acceptable. Without the short field requirement, engine mounted wings offer a lighter wing structure because of bending relief from the engine weight. BUT that has to be traded off against the longer undercarriage that wing mounted engines on a low wing may require. There are also c of g issues with rear mounted engines, if you intend to offer long fuselage variants (like the 757 and the A320 families).
The answer to this question is the standard engineering answer to complex problems: "it depends".